Stress is defined as any type of change that causes physical, emotional or psychological tension, and it has been dubbed as “the health epidemic of the 21st century” by the World Health Organization. Stress is the body’s response to any situation that requires attention or action, and everybody experiences some level of stress. However, high levels of stress may lead to various physical, mental, and emotional symptoms such as muscle tension, headaches, fatigue, sleep disorders, irritability, increased heart rate, and difficulty in breathing. Chronic stress is also a risk factor for the development or exacerbations of non-communicable diseases. Pharmacists have an important role in helping people prevent and manage stress though pharmacological and non-pharmacological approaches.